Rearrangement of DNA fragments: a branch-and-cut algorithm

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Rearrangement of DNA fragments: a branch-and-cut algorithm

In this paper we consider a problem that arises in the process of reconstruction of DNA fragments. We present a graph theoretical formulation of the problem and mention some extensions. We show this problem to be NP-hard. A 0-1 integer linear programming formulation of the problem is given and some preliminary results of a branch-and-cut algorithm based on this formulation are discussed. 1 We t...

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ژورنال

عنوان ژورنال: Discrete Applied Mathematics

سال: 2002

ISSN: 0166-218X

DOI: 10.1016/s0166-218x(00)00324-3